{"id":64268,"date":"2026-10-12T14:57:23","date_gmt":"2026-10-12T12:57:23","guid":{"rendered":"https:\/\/carlosoconnor.es\/?p=64268"},"modified":"2026-10-12T14:57:25","modified_gmt":"2026-10-12T12:57:25","slug":"impacto-de-la-hipoxia-y-la-fragmentacion-del-sueno-en-el-sistema-nervioso-central","status":"publish","type":"post","link":"https:\/\/carlosoconnor.es\/en\/impacto-de-la-hipoxia-y-la-fragmentacion-del-sueno-en-el-sistema-nervioso-central\/","title":{"rendered":"Impacto de la hipoxia y la fragmentaci\u00f3n del sue\u00f1o en el sistema nervioso central"},"content":{"rendered":"

La hipoxia intermitente cr\u00f3nica y la fragmentaci\u00f3n del sue\u00f1o propias de la apnea obstructiva del sue\u00f1o (AOS) no solo comprometen la v\u00eda a\u00e9rea, sino que impactan de forma directa sobre el sistema nervioso central. Una revisi\u00f3n narrativa reciente publicada en Antioxidants (Jaromirska et al., 2026) sintetiza las bases moleculares que vinculan esta patolog\u00eda con un mayor riesgo de deterioro cognitivo leve y demencia, analizando la compleja dualidad entre las cascadas que impulsan la neurodegeneraci\u00f3n \u2014como la desregulaci\u00f3n de la SUMOilaci\u00f3n, la se\u00f1alizaci\u00f3n de los receptores tipo Toll y la hiperactivaci\u00f3n de inflamasomas en modelos experimentales\u2014 y la activaci\u00f3n simult\u00e1nea de adaptaciones neuroprotectoras end\u00f3genas.Este marco conceptual introduce la noci\u00f3n de una \u00abreserva neuroprotectora\u00bb que equilibra el da\u00f1o neuronal inducido por el estr\u00e9s hip\u00f3xico mediante respuestas como el incremento de factores neurotr\u00f3ficos y la eritropoyetina. No obstante, los autores se\u00f1alan que gran parte de estos mecanismos se han caracterizado en modelos animales y experimentales, por lo que su validaci\u00f3n cl\u00ednica sigue siendo una asignatura pendiente para el desarrollo de biomarcadores diagn\u00f3sticos precoces y terapias coadyuvantes dirigidas.<\/p>\n\n\n\n

Enlace de referencia:https:\/\/pubmed.ncbi.nlm.nih.gov\/42792228\/<\/p>\n\n\n\n

#ApneaDelSue\u00f1o #Neuroproteccion #DeterioroCognitivo #MedicinaDelSue\u00f1o #Otorrinolaringologia #HipoxiaIntermitente<\/p>\n\n\n\n

\"images
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La hipoxia intermitente cr\u00f3nica y la fragmentaci\u00f3n del sue\u00f1o propias de la apnea obstructiva del sue\u00f1o (AOS) no solo comprometen la v\u00eda a\u00e9rea, sino que impactan de forma directa sobre…<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-64268","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nImpacto de la hipoxia y la fragmentaci\u00f3n del sue\u00f1o en el sistema nervioso central - Carlos O'Connor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/carlosoconnor.es\/en\/impacto-de-la-hipoxia-y-la-fragmentacion-del-sueno-en-el-sistema-nervioso-central\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impacto de la hipoxia y la fragmentaci\u00f3n del sue\u00f1o en el sistema nervioso central - 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