{"id":64229,"date":"2026-09-30T15:10:27","date_gmt":"2026-09-30T13:10:27","guid":{"rendered":"https:\/\/carlosoconnor.es\/?p=64229"},"modified":"2026-09-30T15:10:31","modified_gmt":"2026-09-30T13:10:31","slug":"uso-del-daridorexant-en-pacientes-con-aos-grave","status":"publish","type":"post","link":"https:\/\/carlosoconnor.es\/en\/uso-del-daridorexant-en-pacientes-con-aos-grave\/","title":{"rendered":"Uso del daridorexant en pacientes con AOS grave"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Evaluar la seguridad respiratoria de las terapias farmacol\u00f3gicas para el sue\u00f1o en presencia de eventos colapsables de la v\u00eda a\u00e9rea superior sigue siendo un tema prioritario en nuestra pr\u00e1ctica. En un ensayo cl\u00ednico cruzado, aleatorizado y doble ciego realizado por Fietze et al. (2026), se evalu\u00f3 el efecto del daridorexant (50 mg) frente a placebo durante 5 d\u00edas en 16 adultos con apnea obstructiva del sue\u00f1o (AOS) grave sin insomnio. Los resultados mostraron que este antagonista dual del receptor de orexina no empeor\u00f3 el \u00edndice de apnea-hipopnea ni la saturaci\u00f3n media de ox\u00edgeno (SpO2), registrando adem\u00e1s un incremento en el tiempo total de sue\u00f1o (+32,5 min) y una menor latencia de sue\u00f1o. Estos hallazgos ofrecen tranquilidad cl\u00ednica respecto al perfil de seguridad respiratoria a corto plazo del daridorexant en pacientes con AOS grave. No obstante, al tratarse de una muestra reducida (16 participantes), de un solo centro y con una exposici\u00f3n limitada a 5 noches, los resultados no pueden generalizarse al uso prolongado ni interpretarse como un tratamiento primario para la colapsabilidad de la v\u00eda a\u00e9rea. Tampoco se evalu\u00f3 el impacto de terapias miofuncionales o pap en combinaci\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Enlace de referencia: https:\/\/pubmed.ncbi.nlm.nih.gov\/42171662\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">#ApneaDelSueno #AOSGrave #Daridorexant #MedicinaDelSueno #Otorrinolaringologia #SeguridadFarmacologica<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"447\" height=\"447\" src=\"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg\" alt=\"images 2026 09 30T080803.621\" class=\"wp-image-64230\" srcset=\"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg 447w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-150x150.jpg 150w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-12x12.jpg 12w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-300x300.jpg 300w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-370x370-1.jpg 370w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-120x120.jpg 120w, https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621-410x410.jpg 410w\" sizes=\"(max-width: 600px) 100vw, 447px\" \/><figcaption class=\"wp-element-caption\">images 2026 09 30T080803.621<\/figcaption><\/figure>","protected":false},"excerpt":{"rendered":"<p>Evaluar la seguridad respiratoria de las terapias farmacol\u00f3gicas para el sue\u00f1o en presencia de eventos colapsables de la v\u00eda a\u00e9rea superior sigue siendo un tema prioritario en nuestra pr\u00e1ctica. En&hellip;<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-64229","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/carlosoconnor.es\/en\/uso-del-daridorexant-en-pacientes-con-aos-grave\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor\" \/>\n<meta property=\"og:description\" content=\"Evaluar la seguridad respiratoria de las terapias farmacol\u00f3gicas para el sue\u00f1o en presencia de eventos colapsables de la v\u00eda a\u00e9rea superior sigue siendo un tema prioritario en nuestra pr\u00e1ctica. En&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/carlosoconnor.es\/en\/uso-del-daridorexant-en-pacientes-con-aos-grave\/\" \/>\n<meta property=\"og:site_name\" content=\"Carlos O&#039;Connor\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-30T13:10:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-30T13:10:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"447\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"gestion\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"gestion\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/\"},\"author\":{\"name\":\"gestion\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#\\\/schema\\\/person\\\/c879dbc2b732eaa32429f50dfbd0a949\"},\"headline\":\"Uso del daridorexant en pacientes con AOS grave\",\"datePublished\":\"2026-09-30T13:10:27+00:00\",\"dateModified\":\"2026-09-30T13:10:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/\"},\"wordCount\":224,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/images-2026-09-30T080803.621.jpg\",\"articleSection\":[\"Uncategorized\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/\",\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/\",\"name\":\"Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/images-2026-09-30T080803.621.jpg\",\"datePublished\":\"2026-09-30T13:10:27+00:00\",\"dateModified\":\"2026-09-30T13:10:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#primaryimage\",\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/images-2026-09-30T080803.621.jpg\",\"contentUrl\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/images-2026-09-30T080803.621.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/uso-del-daridorexant-en-pacientes-con-aos-grave\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/carlosoconnor.es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Uso del daridorexant en pacientes con AOS grave\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#website\",\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/\",\"name\":\"Carlos O&#039;Connor\",\"description\":\"Dr. Carlos O&#039;Connor Reina - Otorrinolaring\u00f3logo\",\"publisher\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/carlosoconnor.es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#organization\",\"name\":\"Carlos O&#039;Connor\",\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/cropped-logo-wide.png\",\"contentUrl\":\"https:\\\/\\\/carlosoconnor.es\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/cropped-logo-wide.png\",\"width\":241,\"height\":50,\"caption\":\"Carlos O&#039;Connor\"},\"image\":{\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/carlosoconnor.es\\\/#\\\/schema\\\/person\\\/c879dbc2b732eaa32429f50dfbd0a949\",\"name\":\"gestion\",\"sameAs\":[\"https:\\\/\\\/www.ycomieronperdices.net\\\/temp\\\/oconnor2025\"],\"url\":\"https:\\\/\\\/carlosoconnor.es\\\/en\\\/author\\\/gestion\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/carlosoconnor.es\/en\/uso-del-daridorexant-en-pacientes-con-aos-grave\/","og_locale":"en_GB","og_type":"article","og_title":"Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor","og_description":"Evaluar la seguridad respiratoria de las terapias farmacol\u00f3gicas para el sue\u00f1o en presencia de eventos colapsables de la v\u00eda a\u00e9rea superior sigue siendo un tema prioritario en nuestra pr\u00e1ctica. En&hellip;","og_url":"https:\/\/carlosoconnor.es\/en\/uso-del-daridorexant-en-pacientes-con-aos-grave\/","og_site_name":"Carlos O&#039;Connor","article_published_time":"2026-09-30T13:10:27+00:00","article_modified_time":"2026-09-30T13:10:31+00:00","og_image":[{"width":447,"height":447,"url":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg","type":"image\/jpeg"}],"author":"gestion","twitter_card":"summary_large_image","twitter_misc":{"Written by":"gestion","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#article","isPartOf":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/"},"author":{"name":"gestion","@id":"https:\/\/carlosoconnor.es\/#\/schema\/person\/c879dbc2b732eaa32429f50dfbd0a949"},"headline":"Uso del daridorexant en pacientes con AOS grave","datePublished":"2026-09-30T13:10:27+00:00","dateModified":"2026-09-30T13:10:31+00:00","mainEntityOfPage":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/"},"wordCount":224,"commentCount":0,"publisher":{"@id":"https:\/\/carlosoconnor.es\/#organization"},"image":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#primaryimage"},"thumbnailUrl":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg","articleSection":["Uncategorized"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/","url":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/","name":"Uso del daridorexant en pacientes con AOS grave - Carlos O&#039;Connor","isPartOf":{"@id":"https:\/\/carlosoconnor.es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#primaryimage"},"image":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#primaryimage"},"thumbnailUrl":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg","datePublished":"2026-09-30T13:10:27+00:00","dateModified":"2026-09-30T13:10:31+00:00","breadcrumb":{"@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#primaryimage","url":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg","contentUrl":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2026\/09\/images-2026-09-30T080803.621.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/carlosoconnor.es\/uso-del-daridorexant-en-pacientes-con-aos-grave\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/carlosoconnor.es\/"},{"@type":"ListItem","position":2,"name":"Uso del daridorexant en pacientes con AOS grave"}]},{"@type":"WebSite","@id":"https:\/\/carlosoconnor.es\/#website","url":"https:\/\/carlosoconnor.es\/","name":"Carlos O&#039;Connor","description":"Dr. Carlos O&#039;Connor Reina - Otorrinolaring\u00f3logo","publisher":{"@id":"https:\/\/carlosoconnor.es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/carlosoconnor.es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/carlosoconnor.es\/#organization","name":"Carlos O&#039;Connor","url":"https:\/\/carlosoconnor.es\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/carlosoconnor.es\/#\/schema\/logo\/image\/","url":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2025\/07\/cropped-logo-wide.png","contentUrl":"https:\/\/carlosoconnor.es\/wp-content\/uploads\/2025\/07\/cropped-logo-wide.png","width":241,"height":50,"caption":"Carlos O&#039;Connor"},"image":{"@id":"https:\/\/carlosoconnor.es\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/carlosoconnor.es\/#\/schema\/person\/c879dbc2b732eaa32429f50dfbd0a949","name":"gestion","sameAs":["https:\/\/www.ycomieronperdices.net\/temp\/oconnor2025"],"url":"https:\/\/carlosoconnor.es\/en\/author\/gestion\/"}]}},"_links":{"self":[{"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/posts\/64229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/comments?post=64229"}],"version-history":[{"count":1,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/posts\/64229\/revisions"}],"predecessor-version":[{"id":64231,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/posts\/64229\/revisions\/64231"}],"wp:attachment":[{"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/media?parent=64229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/categories?post=64229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/carlosoconnor.es\/en\/wp-json\/wp\/v2\/tags?post=64229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}